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Microglia activation and neuroinflammation in ASD Microglial activation was assessed via Iba1 immunofluorescence staining in the hippocampal CA1 region and prefrontal cortex of VPA-exposed SD rats to evaluate neuroinflammatory pathology

*Correspondence: Santao Ou, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The nuance is that a large share of autistic patients also show undermethylation traits, where aggressive folate therapy can occasionally activate irritability, anxiety, or sleep disruption

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