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Furthermore, oligodendrocytes in aged mice (18-months-old) release factors that promote microglial-mediated survival of oligodendrocytes, but prevent OPC differentiation (Luan et al., 2021)

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It causes an immediate release of almost all the granules (containing serotonin, histamine, chemokines, cytokines, enzymes, heparin, and prostaglandins), which trigger itching, swelling, mucous, and anaphylaxis.[ref] A delayed response by mast cells comes from the formation of other mediators, such as prostaglandin D2