In April 2025 Pfizer was forced to discontinue a clinical trial with one of its experimental GLP-1 medicines to treat obesity due to potential drug induced liver injury found in one of the participants
Centrally Mediated Satiety (The Brain Connection) GLP-1 is capable of crossing the blood-brain barrier or signaling via the vagus nerve to reach the hypothalamus, the brains control center
18 To keep that valuation, they have built patent thicketsdense forests of intellectual property designed to keep generics and compounders out for decades
Gerstein HC, Jung H, Ryden L, Diaz R, Gilbert RE, Yusuf S, et al
Rushing this schedule is the single most common reason people experience severe nausea, vomiting, and other GI side effects that make them abandon the medication entirely
10.1007/s00395-015-0476-7 65 RochoJ.KalinowskiP.Szymanek-MajchrzakK.GrtM