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The difference comes from how many hormone pathways each medication targets

Several studies have highlighted oxidative stress as a key factor in ME/CFS

Use of SSRIs did not appear to influence circulating concentrations of MPO ( p = 0.522), MMP-9 ( p = 0.645), nor TIMP-2 ( p = 0.337)

Medical Foods Medical Food products are often used in hospitals (e.g., for burn victims or kidney dialysis patients) and outside of a hospital setting under a physicians care for the dietary management of diseases in patients with particular medical or metabolic needs due to their disease or condition

No clinical trials have been completed in humans to date [8]