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Obstacles in clinical trials A problem is the lack of selectivity of the available drugs and their consequent undesirable side effects for the patients (163)

Ramsey, J., Martin, E

& Drucker, D

Mol Cell Endocrinol 464, 65-74 (2018)

These models demonstrate that rats treated with SFN exhibit increased sniffing times and greater engagement with unfamiliar rats during social tests, suggesting an improvement in social cognition and interaction

Children metabolize tacrolimus more rapidly, so doses are often higher per kilogram of body weight, typically 0.15 to 0.3 mg/kg/day, divided twice daily