PGC-1, a pivotal regulator of mitochondrial biogenesis and cellular resistance to oxidative stress, plays a pivotal role in the function and survival of dopaminergic neurons in the substantia nigra (Halling and Pilegaard, 2020)
This enzyme is thus of great therapeutic significance
Antisense oligonucleotide and adjuvant exercise therapy reverse fatigue in old mice with myotonic dystrophy
Delicate metabolic control and coordinated stress response critically determine antifungal tolerance of Candida albicans biofilm persisters
Neurologic Diseases The nervous system, particularly the brain, is highly vulnerable to oxidative damage due to its high energy and oxygen consumption, the large concentration of PUFAs in myelin membranes, and its relatively low antioxidant defenses [180,181]
doi: 10.3390/molecules24071298