Response-Based Approach: Treatment duration is individualized based on objective measurements including body composition analysis (DEXA scan, bioimpedance), waist circumference, metabolic markers, and subjective response
Human Data: Endogenous plasma levels of MOTS-c are observed to increase following human exercise, linking it directly to exercise biology
Also studied for inflammation modulation, angiogenesis, and neural tissue protection
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Researchers initially examined it in the context of obesity and metabolic-syndrome research models, exploring whether modulating NNMT alters markers of substrate utilisation and energy expenditure