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Intramuscular and intravenous delivery bypasses the gastrointestinal tract, achieving significantly higher bioavailability than oral supplementation, making injectable micronutrients a clinically effective option for patients with confirmed or suspected deficiency, malabsorption conditions, or chronic illness

The SL overcomes the challenges of IM injections and should be the first line option for patients with VB12d

The absence of established treatment protocols makes it difficult to determine optimal dosing regimens, treatment duration, and comprehensive monitoring requirements

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16 studies were review, meta-analysis and commentary and 2 studies were identified as overlapping studies