The Saccharomyces cerevisiae copper transport protein (Ctr1p)
Zhang NY, Hou DY, Hu XJ, Liang JX, Wang MD, Song ZZ, et al
2 PBMs are passing more of the rebates back to plan sponsors (i.e., using them to reduce premiums) than they have historically
The cells were cultured in Dulbeccos Modified Eagles Medium/Nutrient Mixture F-12 (DMEM/F12 = 1:1) supplemented with 5% (v/v) fetal bovine serum, 1 mM pyruvate, 50 g/mL penicillin, 50 g/mL streptomycin, 10 g/mL insulin, 5.5 g/mL transferrin, 5 ng/mL sodium selenite, and 5 ng/mL epidermal growth factor and maintained at 37 C in a sterile, humidified atmosphere of 5% CO 2
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The authors propose that the alternate version of GLP1R gene creates a protein that is functionally the same, but is moved more efficiently through the cell to the surface, where it can be targeted by the drug