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Site rotation prevents lipodystrophy (changes in fat tissue at the injection site) and reduces the risk of persistent injection site reactions

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With research characterising promotion of tenocyte migration and proliferation, angiogenic support of the healing tendon, and anti-inflammatory effects that reduce the chronic inflammatory environment that impairs tendon repair

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It occurs more commonly in people who have other autoimmune diseases such as thyroid diseases, Addisons disease and vitiligo