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Specifically, the indirect mechanism is chelation of transition metals, which prevents participation within the Haber-Weiss (Kehrer, 2000) or Fenton reaction, while the direct mechanism involves donating or receiving of electrons, scavenging radicals, and consequently preventing their reaction with biological molecules
There is a possible link between potential oxidant effects of nicotine demonstrated in this study and its modulation of ALP mediated actions 47 , collagen and ECM formation in fibroblasts 50 , which could contribute to the effects of nicotine on wound healing, applicable to the cells used in our investigation
Abstract Coronary heart disease (CHD), a serious cardiovascular condition with complex and diverse pathogenesis, has recently seen increased attention to the role of ferroptosisa novel iron-dependent form of programmed cell death
The net result of this mechanism of action is that overexpression of melanin is attenuated which means less hydrogen peroxide production and localized hyperpigmentation
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