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Then in May 2025, the first direct head-to-head trial SURMOUNT-5 was published in the New England Journal of Medicine , putting the two medications head-to-head in the same patients, at the same time, under the same conditions
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Mounjaro, on the other hand, contains tirzepatide and targets both the GLP-1 and Gastric Inhibitory Polypeptide (GIP) hormone pathways, making it a dual agonist
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