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Concurrently, exercise, a cornerstone in the prevention and management of chronic diseases, plays a critical role in regulating disease progression

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This indicates that felinine production downregulates cholesterol biosynthesis, as the in vivo synthesis of cholesterol is affected by cholesterol intake, resulting that Tsushima leopard cats may use more isopentenyl diphosphate for the cholesterol biosynthesis rather than felinine production in winter season as compared to Iriomote cats

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