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With age, endogenous synthesis decreases and needs increase (slower recovery, sarcopenia)

J Infect Dis 177:14651474

Frstermann U, Sessa WC

doi: 10.1080/17425255.2019.1650914

NF-B Pathway LPO products such as 4-HNE have been shown to interfere with NF-B activation at the level of IB kinase (IKK) which is an important molecule phosphory-lating IB for its degradation [14, 128]

Data synthesis and analysis All relevant baseline characteristics and study outcomes were independently extracted by AS, SF and KM, using a standardized digital extraction form, including treatment effects in patient subgroups defined by the presence or absence of CKD