This makes it a perfect partner for GHK-Cu
J.AguilarB
A modeling perspective"
doi: 10.3389/fnut.2025.1612919 Received 16 April 2025 Accepted 05 September 2025 Published 19 September 2025 Volume 12 - 2025 Edited by Karolina Krupa-Kotara, Medical University of Silesia, Poland Reviewed by Ajibola Ibraheem Abioye, Harvard University, United States Sreenivasulu Chintala, Indiana University School of Medicine, United States Updates Copyright 2025 Li and Zhu
The reaction reflects regenerative signalling and barrier disruption during the adjustment period, not permanent harm
Breaks make sense for users experiencing treatment plateau where benefits cease increasing despite continued application suggesting diminishing returns from ongoing use, comfortable with some benefit decline during off periods accepting fluctuation in skin quality, budget-conscious seeking to minimize annual treatment costs through intermittent purchasing, philosophically preferring avoiding indefinite dependency on any skincare product, planning life changes incompatible with consistent application (extended travel, relocation, financial shifts), and wanting to assess whether improvements prove durable or require continuous maintenance before committing to indefinite treatment
