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An increase in intracellular ROS is a major signal that reacts with intracellular iron to produce more active ROS-type hydroxyl radicals (HO) that trigger ferroptosis [81]

Ruan et al., 2020

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doi:10.1093/nutrit/nuz082 Martnez-Gonzlez MA, Fernandez-Lazaro CI, Toledo E, et al

Glutathione inhibits tyrosinase, an enzyme in melanin production, which can gradually lead to more even skin tone and reduced dark spots

The plug protrudes into the renal pelvis and is exposed to the urine, further promoting the formation of small stones behind the plug