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Dose increases during the second and third months typically produce noticeable appetite suppression and measurable weight loss

So aim for at least eight glasses of water a day

Patients with significant sarcopenia (low lean muscle relative to fat mass) or high visceral adiposity may warrant consideration of combination therapy to preserve muscle during rapid weight loss

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Additionally, some users have reported joint and muscle pain

Almost 63% of participants who received semaglutide had steatohepatitis resolution without their fibrosis getting worse