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Inflammatory factors (e.g., TNF-, IL-6) and ROS associated with IBD impair the capacity of cells to repair lipid peroxidation by inhibiting the activity or expression of GPX4, synergizing with iron overload to significantly lower the threshold for epithelial cells to undergo ferroptosis

Specifically, it is recommended to discontinue breastfeeding during MB therapy and for up to 8 days after the last dose, to allow the drug to clear from the mothers system

Proc Natl Acad Sci U S A 111(11):40014006

29 ShieldsD

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Firman, R