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The critical role and molecular mechanisms of ferroptosis in antioxidant systems: a narrative review

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Discussion and conclusions Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare types of severe drug hypersensitive reactions with high mortalities (4.8% for SJS and 14.8% for TEN, respectively) [10]

Consistently, the DHODH inhibitor Brequinar specifically promotes ferroptosis in GPX4-low-expressing cells by reducing mitochondrial CoQ10H 2 levels (110)

Airaksinen EM