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The review also covered three therapeutic research strategies: direct GSH depletion (leading to ferroptosis or enhanced chemotherapy sensitivity), indirect approaches targeting the tumour microenvironment, and prodrug strategies utilising elevated tumour GSH for drug activation

Michael Schwartz received his MD from Rush Medical College and trained in endocrinology and metabolism at the University of Washington

J Clin Biochem.Nutr

360 The immunoconjugate was obtained by covalently attaching antibodies (a-CTLA-4 IgG2b, or a-PD-1 IgG) to poly(-L-malic acid) polymers, with pre-conjugation of anti-mouse transferrin receptor antibody, and trileucine

(ii) the small number of individuals investigated

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