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Rapid weight changes can affect spinal loading patterns and muscular support, potentially contributing to transient back discomfort as the body adapts

10.1016/j.cmet.2019.01.020 15 HemaniG.ZhengJ.ElsworthB.WadeK

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Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice

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Some goals patients have include weight loss, but also just as importantly, if not more so, nonscale goals like improved mobility, more energy through the day, less chronic pain in their joints, and feeling more confident in their bodies, she says