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This result indicates that chronic treatment with GLP-1R agonists could lead to proliferation/chronic activation of PSCs, with serious side effects

Zhou K, Huo M, Ma W, Mi K, Xu X, Algharib SA, et al

van der Pols JC, Xu C, Boyle GM, Hughes MC, Carr SJ, Parsons PG, et al

Alcohol: The company's provider guides advise limiting or avoiding alcohol during treatment, especially during dose adjustments, as it may worsen nausea, low blood sugar, or dehydration

Of note, intracerebroventricular injection of the MOR antagonist naloxone has also been shown to improve opioid-induced constipation 11 , suggesting a role for the brain-gut axis in this condition 12,13

BPC-157 is acid-stable, so oral delivery is viable