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They can be rapidly degraded by enzymes, leading to a short half-life

By activating both GLP-1 and GIP receptors, Tirzepatide enhances these natural processes, leading to better blood sugar control and reduced hunger

Thyroid C-cell tumors in animal studies prompted FDA monitoring requirements, though human thyroid cancer risk remains under investigation

where n T and n C is the minimum sample size of the ecnoglutide group and the placebo group, respectively, d is the expected difference of mean change from baseline in HbA1c between the ecnoglutide groups and the control group, is the superiority margin (0.3%), S c is the common standard deviation of change from baseline in HbA1c, is the type I error (one-sided), which is 0.025 in this study, and is the type II error

Lancet Neurol 22:11041105