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When to Talk With a Doctor Patients should consider speaking with a physician if they have persistent fatigue, unexplained weight changes, poor recovery, worsening brain fog, low exercise tolerance, recurrent crashes, symptoms after rapid weight loss, or interest in NAD+ or MOTS-c therapy

Using them can cause serious and potentially life threatening reactions"

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In FM patients, increased expression of FXR pathways has been reported 54 , with the authors suggesting that this increased activation of FXR pathways may be a response to chronic inflammation