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Clinical applications of CUR in OSF treatment Systemic administration of CUR The systemic administration of CUR is associated with favorable safety profiles, as no toxicity has been reported at doses as high as six grams daily for several weeks

Using MRI-proton density fat fraction measurements, researchers documented mean decreases in liver fat content of 65 to 80% depending on dose

In our study ( we observed that while weight loss remains an important driver of response in MASH, there are also signals consistent with weight-lossindependent pathway modulation, of inflammatory and fibrotic biological processes

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Wilding et al., NEJM 2021)

Extended treatment options with individualized dosing schedules