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Accessed 6 th March 2026

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(Right) GLP-1 receptor agonist (GLP-1RA) reduces cholesterol accumulation by affecting the expression of genes in the hepato-enteral circulation and cholesterol reverse transport pathway, such as farnesoid X receptor (FXR), fibroblast growth factor-15 (FGF15), fibroblast growth factor receptor 4 (FGFR4), cytochrome P450 family 7 subfamily A member 1 (Cyp7a1), proprotein convertase subtilisin/kexin type 9 (PCSK9), low-density lipoprotein receptor (LDLR), etc

These studies should incorporate sensitive biomarkers, including neuroimaging (MRI-based volumetry and functional connectivity), cerebrospinal fluid A/tau ratios, and emerging blood-based markers of oxidative stress and inflammation

( A ) Expression levels of PCSK1 , IAPP , and MAFA projected on the UMAP generated from human islet cells treated with saline (CTRL) or liraglutide (LIRA)