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Exendin-4 and DPP-4 deficiency prevented vasoconstriction and multiple organ injury after LPS treatment, and improved survival in endotoxemic rats ( In animal studies, GLP-1 and its analogs reduced macrophage infiltration in blood vessels, and production of pro-inflammatory cytokines such as IL-6, IL-1, TNF-, and CRP

& Stallone, J

29 This discrepancy may suggest once more that animal models may differ from settings in humans, making extrapolations from animals to humans difficult