Chronic activation of microglia amplifies these effects: activated microglia release free radicals, glutamate, and pro-inflammatory cytokines that perpetuate the inflammatory response and induce synaptic damage [273]
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Harpagoside, one of its active constituents, exerts neuroprotective effects by modulating endoplasmic reticulummitochondria coupling (MAMs), suppressing IP3R1/GRP75/VDAC1 complex expression, and maintaining neuronal calcium homeostasis
Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism
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Vitamin Levels in Adults with ADHD
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