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The reason is that the carbonsulfur lyase (CSL) enzymes originating from yeast (Irc7 and Str3 are the most well studied) have low activity toward 3MH precursor

[DOI] [PubMed] [Google Scholar] Yaney GC, Korchak HM, Corkey BE

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Causes and consequences of discontinuation of GLP1RAs or tirzepatide

Phytochemistry 67 , 23182331 (2006)