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The absolute risk increase for diabetic retinopathy complications was greater among patients with a history of diabetic retinopathy at baseline (semaglutide 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide 0.7%, placebo 0.4%)

In severe cases, doctors may recommend hydroxocobalamin injections for the rest of the persons life

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Another early change is finer, softer individual hairs in the crown region

High-fat diets have been shown to exacerbate insulin resistance and impair glucose oxidation, while caloric restriction and ketogenic diets have been associated with improved metabolic flexibility and reduced reliance on lipid metabolism (44)