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The stage of hepatic fibrosis predicts both overall and liver-related mortality and is the strongest predictor of long-term clinical outcomes, with advanced fibrosis (stages 3 and 4) conveying the highest risk of mortality [6]

65 Early investigations revealed that SSc patients exhibited higher levels of CD4+ DPP4+ T cells in their peripheral blood, and DPP4 activity in T cells was associated with disease severity