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However, for most agents, including warfarin and digoxin, overall systemic exposure is not clinically meaningful, and routine dose adjustments are generally unnecessary

He L, Wang J, Ping F, et al

Cell 80 , 485500.e7 (2020)

Daily doses of 1,000 mcg have been reported as necessary in many cases to accommodate a wide range of Vitamin B12 use and storage in different people

It has been shown to promote the healing of ulcers, protect the stomach lining from damage, and reduce inflammation in the gut