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These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

The mean duration of diabetes was 14.9 years and mean BMI was 32 kg/m2

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doi: 10.1007/s00284-017-1396-6 483 ZhangQ.LiuF.ZengM.MaoY.SongZ

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It is vital for optimal cellular health