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Results: Incidence rates for pancreatitis (adjusted HR [aHR] 9.1, 95% confidence interval [CI] 1.25-66), bowel obstruction (aHR 4.2, 95% CI 1.02-17.4), and gastroparesis (aHR 3.7, 95% CI 1.2-11.9) were significantly higher among users of GLP-1 receptor agonists compared to buproprion-naltrexone users

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Untargeted lipidomics using UPLC-ESI-MS/MS The dried lipid extracts were reconstituted with 60 L of isopropanol/methanol (1:1, v/v) and then separated on a Waters C18 column (Waters ACQUITY, 2.1 100 mm, 1.7 m) connected to a Vanquish UPLC solvent delivery system (Thermo Scientific, San Jose, CA, USA)

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