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A third, recent study in JAMA Network Open , from August of 2025, analyzed data from 159,000 people with type 2 diabetes who took semaglutide or tirzepatide (Mounjaro, Zepbound)

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"Is there a way to lose the least possible muscle mass, and is there a way not to drop your resting metabolic rate, or your basal metabolic rate, too much? Ravussin said.