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Moreover, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IB) phosphorylation, nuclear translocation of p65, p50, and p105 NF-B subunits, and NF-B DNA-binding transcriptional activity were suppressed by XN treatment of DSS-treated mice and H 2 O 2 - or LPS-treated IEC-6 cells ( XN protects mice from DSS-induced colitis and H 2 O 2 - or LPS-treated IEC-6 injury, possibly by the interaction between the , -unsaturated carbonyl moiety of XN and Cys99 in IKK, and thus by its ability to inhibit the IKK/NF-B signaling pathway

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