The pooled estimates may be underestimates of the efficacy of newer agents, although the review could not determine whether stronger weight-loss effects necessarily translate into greater reductions in binge eating
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It is an exceptional pathway for individuals sensitive to standard medication side effects, patients managing autoimmune conditions like Hashimotos or PCOS, or those looking to maintain prior weight loss long-term
10.4103/0019-5545.44908 [DOI] [PMC free article] [PubMed] [Google Scholar] Ochiai T., Sano T., Nagayama T., Kubota N., Kadowaki T., Wakabayashi T., et al
Future direction The evolution of GLP-1RAs is increasingly shifting toward oral formulations, aiming to enhance patient adherence by eliminating the need for injections and addressing the logistical complexities associated with traditional peptide therapies [72, 73]
More than half of patients (53%) stop using GLP-1s within the first year, according to a December 2025 Sermo survey of physicians