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For example, analysis of data from the SURPASS-3 trial by Viljoen et al

By understanding the causes, risks, and treatment options for bleeding gums, you can take proactive steps to maintain your oral health and prevent more severe problems from developing

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Its primary endpoint was measured at week 72, not at week 4 or week 12, and the trial's own structure tells you something: the sponsor and the FDA both expected meaningful change to accumulate across more than a year of treatment

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In short, it is a personalization strategy, not a formally validated alternative to labeled dosing