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In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation

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This immobility slows down blood flow, which can cause clots to form

Cardiometabolic risk minimization: Due to its impact on weight and glucose metabolism, Retatrutide may potentially reduce long-term cardiovascular risk factors (such as high blood pressure), though definitive outcomes are still under investigation