I., Hussain, I., Kasiri, S
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Semaglutide activates GLP-1 receptors alone, while tirzepatide activates both GLP-1 and GIP receptors, often producing faster or greater weight loss (up to 22% in trials)
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In practice, that means a dose below the lowest approved dose: under 2.5 mg of tirzepatide or 0.25 mg of semaglutide