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Regulatory agencies, such as the FDA, are closely monitoring these findings and have recently advised caution regarding the use of GLP-1 drugs for people who may already be at higher risk of DVT

However, certain lignans, such as gomisin B, gomisin C and gomisin G, are not BBB permeable, which may limit their use as central nervous system targets

Eli Lilly on Thursday said its next weight loss drug retatrutide, which targets three hormones instead of the usual one or two, delivered nearly 17% weight loss in patients with type 2 diabetes over 40 weeks in its first Phase 3 trial

This side effect usually improves after a few weeks or with dosage adjustments

N Engl J Med 2008;358:25452559

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