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Bitter taste receptors arent only on our tongue, but throughout much of our digestive tract, on the very same cells lining our gut that secrete the appetite-suppressing hormone GLP-1

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Since a K ATP channel-dependent action of GLP-1 is likely to explain insulin secretagogue properties of GLP-1 in patients with T2DM, it is useful to summarize what is known concerning this effect

J., Robinson, P

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2,9,10 A key clinical consequence of this property is that linagliptin can be used without dose reduction in patients with declining renal function