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By reducing systemic inflammation, the KD may help alleviate pelvic pain and other inflammatory symptoms associated with the disease [11,12,13]

This medication is also titrated, and the starting dose is typically 0.5 mg

The formula includes strains like Lactobacillus and Bifidobacterium bifidum, which are known to help maintain a balanced gut microbiome and support the growth of beneficial microorganisms, further boosting the overall effectiveness of the formula

Synovial inflammation is associated with pain sensitization in patients with knee OA 46 , suggesting a role of pro-inflammatory mediators in this process 39

Additionally, another transcription factor, AP-1 (activating protein-1) is significantly involved in the cellular stress response of melanocytes