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Currently, there is a lack of robust clinical data supporting the safety and efficacy of glutathione injections for skin-lightening purposes, which raises concerns about their long-term impact on natural melanin production

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Nakashima and Yamaguchi-Shinozaki 2013)

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Modified drugs (peptides, aptamers, antibodies) either surface or tissue may be effectively delivered through it [139]

Elimova E, Kim SM, Wang X, Shimodaira Y, Sohn BH, Skinner HD, Lee JH, Weston BR, Bhutani MS, Minsky B, Rice DC, Hwang JE, Swisher SG, Hofstetter WL , Blum MA, Maru D, Ajani JA, Lee JS