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These medications are generally considered for adults with: Obesity Overweight alongside weight-related health conditions Difficulty achieving effective weight loss through diet and exercise alone Some patients with type 2 diabetes may also benefit from GLP-1 medications because of their role in blood sugar control

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During stress, the latent monomer of heat shock factor (HSF)-1 is rapidly converted to a trimeric form active in the nucleus to bind to the promoters of HSF-responsive heat shock genes and activate their transcription [94, 95]

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