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Se aconseja suspender el tratamiento al menos 2 meses antes de un embarazo planificado en el caso de semaglutida

"Emerging pharmacotherapies for obesity: A systematic review"

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Depending on the medication and the patient population, research and approvals have supported benefits in areas like: Cardiovascular risk reduction in adults with established cardiovascular disease and overweight or obesity (for specific products) Kidney protection in people with type 2 diabetes and chronic kidney disease (semaglutide showed benefit in a large kidney outcomes trial) Obstructive sleep apnea in adults with obesity (tirzepatide has an FDA-approved indication for moderate to severe OSA in this population) Fatty liver disease and MASH (semaglutide has shown promising results in phase 3 research) Addiction to opioids and alcohol This is why these medications are now part of bigger medical conversations: heart, kidney, liver, sleep health and substance abuse

The study "Liraglutide versus placebo as an adjunct to glucose-lowering therapy in patients with type 2 diabetes and moderate renal failure" (LIRA-RENAL) did not demonstrate a benefit of liraglutide in lowering eGFR, although the duration of the study (26 weeks) may have been insufficient to show an effect

Higher dose data is absent