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As mentioned above, the link between TNF- and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30

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Simultaneously, the acetyl-CoA produced during this process can serve as a precursor for de novo fatty acid synthesis within the cell (Poitelon et al., 2020)