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[120] identified one of these non-opioid receptor targets as being adrenergic receptors, observing that three kappa opioid receptor agonists bound in the mid- to high-nanomolar range to alpha-1a adrenoceptors, one acting as a potent functional enhancer

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Multivariable Cox models were adjusted for age, sex, race/ethnicity, body mass index, treatment year, Alcohol Use Disorders Identification Test (AUDIT-C) score, Model for End Stage Liver Disease (MELD-Na) score, cirrhosis, ascites, and hepatic encephalopathy on admission