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Clinicians should counsel patients that while GLP-1 medications offer proven benefits for diabetes and weight management, they should not be considered cortisol-lowering agents

Reports of temporary tiredness or mild headaches when first starting have been reported

Kawahara et al., 2009)

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Similarly, liraglutide, another GLP-1 agonist, requires daily injections and results in moderate weight loss approximately 8% of the initial body weight

For example, so much water is removed or redirected from the Colorado River in the western United States that, despite its considerable size, in some years it is dry before reaching the sea in Mexico