197 HodEAZhangNSokolSAWojczykBSFrancisROAnsaldiDet al
It's a very powerful medication
It may become one of the most promising clinical advances in oral incretin therapy
The combined effect creates a metabolic state where appetite is significantly reduced, gastric emptying is slowed (meaning food stays in the stomach longer and meals feel more satisfying), insulin dynamics are optimized for fat mobilization rather than fat storage, and resting energy expenditure is elevated through glucagon-mediated thermogenesis
In addition, there was upregulation in the expression of the proinflammatory cytokine Tnf and genes involved in the integrated stress response ( Atf3 , Atf5 , Ddit3 and Dele1 ) and reduced expression of the adipokine Adipoq
Jardine MJ, Hata J, Woodward M, et al